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Forensic Medicine General 9bfc2868

Which of the following enzyme is affected in cyanide poisoning?

A
G-6-P dehydrogenase deficiency
B
Isomerase
C
Cytochrome oxidase
D
None of the above
High-Yield Explanation
Cyanide inhibits the action of cytochrome oxidase and carbonic anhydrase. It blocks the final step of oxidative phosphorylation and prevents the formation of ATP and its use as energy source. Cyanide acts by reducing the oxygen carrying capacity of blood, and by combining with the ferric iron atom of intracellular cytochrome oxidase, preventing the uptake of oxygen for cellular respiration. Ref: The Essentials of Forensic Medicine and Toxicology by KS Narayan Reddy, 27th edition, Page 558-559.

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