A 5 year old child suffering from nephrotic syndrome is responding well to steroid therapy. What would be the most likely finding on light microscopy:
High-Yield Explanation
Light microscopy in minimal change disease shows no significant abnormality. Electron microscopy shows obliteration of epithelial cell footprocess. Immunofluorescence shows absence of immunoglobulin or complement deposition. Ref: Kliegman, Behrman, Jenson, Stanton (2008), Chapter 537, "Nephrotic syndrome", In the book, "NELSON TEXTBOOK OF PEDIATRICS", Volume 2, 18th Edition, New Delhi, Pages 2192-93 ; O P Ghai Essential Pediatrics, 6th Edition, Page 451