Pathology General 9b8feba2 Which of the following is the most common mutation in Ewing's sarcoma - A Translocation X : 18 B Translocation 11; 22 C Activative mutation of G5alpha surface protein D Missense mutation in EXTI High-Yield Explanation Ewing's sarcoma is typically characterized by a translocation t (11; 22) (q 24; q12) in up to 90% of patients.