Most common type of human papilloma virus causing Ca cervix are:

It is now established that HPV plays a major role in cervical carcinogenesis. Among the various genotypes (more than 100) the Genotype of HPV which is: Most commonly associated with squamous cell carcinoma cervix - HPV 16 Most common genotype associated with adenocarcinoma of cervix - HPV 18 Overall MC genotype associated with invasive carcinoma, CIN II and CIN III - HPV 16 But HPV 16 is not very specific as it is seen in 16% of women with low grade lesion and 14% women with normal cytology so: - HPV 18 Most specific genotype of HPV for invasive tumor                                                                            The cytological changes caused by HPV are collectively called as Koilocytosis. In most of the females HPV infection clears in 9-15 months , only in small minority it persists. Malignant transformation requires expression of E6 and E7 HPV oncoproteins.