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Pharmacology Anti-Neoplastic Agents 9b3a1f2a

Pulmonary fibrosis is a side effect of

A
Methotrexate
B
Vincristine
C
Bleomycin
D
Cyclophosphamide
High-Yield Explanation
Ans. is 'c' i.e., Bleomycin Pulmonary infiltrates are seen with 3 of the given options - Methotrexate Bleomycin CyclophosphamidePulmonary fibrosis is seen with two of the given optionsBleomycin (Page 1395 G & G 10th/e)Cyclophosphamide (page 1430 G & G 10th/e)I have gone for Bleomycin because pulmonary involvement is most common with Bleomycin."The most serious adverse reaction to Bleomycin is pulmonary toxicity, which begins with dry, cough, fine rales, and diffuse basilar infiltrates on x-ray and may progress to life threatening pulmonary fibrosis"

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