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Medicine General 9a99628b

Gout can be precipitated by all of the following, except:

A
Thiazides
B
Furosemide
C
Cyclosporine
D
High Dose Salicylates
High-Yield Explanation
Answer is D (High Dose Salicylates): Hyperuricemic Syndromes: Pathophysiology and Therapy (Karger Medical and Scientific Publishers, 2005)/ 9 High Dose Salicylates are uricosuric and do not cause Hyperuricemia. Diuretics including Thiazides and Furosemide are known to cause Hyperuricemia. Cyclosporine and Tacrolimus are also associated with Hyperuricemia. High Doses of Salicylates > 3.0 g/day are uricosuric, while Low doses(0.3 to 3.0 g/day) are associated with uric acid retention and Hyperuricemia

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