Na dependent glucose transpo is/are inhibited by

phlorizin inhibits the intestinal glucose transpoer. is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transpo, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as empagliflozin, canagliflozin and dapagliflozin. Phlorizin is not an effective drug because when orally consumed, it is nearly entirely conveed into phloretin by hydrolytic enzymes in the small intestine. Ref guyton and hall textbook of medical physiology 12/e 938