Which of the following medications is contraindicated in patients with allergy to sulphonamides?
High-Yield Explanation
Acetazolamide, Dorzolamide and Brinzolamide are sulfonamide derivatives which act by inhibiting carbonic anhydrase (carbonic anhydrase inhibitor). Being sulphonamide derivatives they are contraindicated in patients with allergy to sulphonamides. Ref: Essentials of Pharmacology By K D Tripathi, 5th Edition, Pages 188, 553; Medicinal Chemistry By Sriram, Page 227.