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Pharmacology Anti-HIV Drugs 9901fc97

Eirenz limits HIV infection by:

A
Binding to active site of HIV reverse transcriptase
B
Impairing the binding of HIV virion to CD4 receptors on T- cells
C
Inhibiting the HIV protease
D
Serving as an allosteric inhibitor of HIV reverse transcriptase
High-Yield Explanation
Eirenz is a NNI which acts as an allosteric (non-competitive) inhibitor of HIV reverse transcriptase. It is more potent than zidovudine on HIV-1, but do not inhibit HIV-2. If used alone, viral resistance develops rapidly by point mutation of the enzyme; therefore it should always be combined with 2 other effective drugs. S/E of Eirenz : Headache, rashes, dizziness, insomnia, neuro-psychiatric symptoms

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