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Pharmacology Mycobacterial Diseases (TB, Leprosy and MAC) 98a560ab

Which of the following statements regarding drugs used in leprosy is FALSE?

A
Single intramuscular injections of acedapsone maintain inhibitory levels of dapsone in tissues for upto 3 months
B
Monthly doses of rifampicin delay the emergence of resistance to dapsone
C
Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone
D
Clofazimine may cause changes in the skin colour
High-Yield Explanation
Acedapsone is a repository form of dapsone. Single i.m. injection of acedapsone keep on releasing the drug for 3 months. Rifampicin is used once in a month (supervised dose) for the treatment of leprosy. It prevents the emergence of resistance to dapsone. Clofazimine can result in skin pigmentation(reddish-black), discolouration of secretions and dryness of skin (icthyosis). Clofazimine has no cross-allergenicity with dapsone.

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