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Pharmacology NEET Jan 2020 984e2dc8

A boy is planning to travel by bus. Which of the following drug can be used to prevent motion sickness in this person?

A
Promethazine
B
Cetrizine
C
Loratidine
D
Fexofenadine
High-Yield Explanation
1st Generation 2nd Generation Cross BBB, cause sedation Do not cross BBB, no sedation Arch - Anticholinergic SLE occur No Ach Useful forMotion SicknessDrug induced parkinsonismMuscular dystoniasAllergy Useful only for allergy Promethazine (max.action)DiphenhydramineDiphenhydrinatePheniramine Chlorpheniramine CyclizineCinnarizine Terfinadine - not used (TDP)Fexofenadine - Terfinadine metaboliteAstemizole - not used (TDP)LoratidineDes loratidineCetrizine, LevocetrizineAzelastine, Olapatadine - Topical

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