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Anatomy General anatomy 98186f26

Resistance to Zidovudine develops due to

A
Mutation at reverse transcriptase
B
Increased efflux of the drug from inside the cell
C
Increased metabolism of drug
D
Decreased Zidovudine 5 triphosphate formation
High-Yield Explanation
Zidovudine is a nucleoside reverse transcriptase inhibitors which is a viral enzyme .HIV undergoes mutations in this enzyme to become resistant to NIs Refer :KDT 6/e p770

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