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Pharmacology General 97e48755

Which of the following is not a clinical sign of atropine intoxication?

A
Flushing of the face
B
Dry skin
C
Increased bowel sounds
D
None of the above
High-Yield Explanation
Atropine is an anticholinergic drug. It will decrease GI motility. PHARMACOLOGICAL ACTIONS of Atropine: Atropine  blocks  all  subtypes  of  muscarinic receptors. Tone and amplitude of contractions of stomach and intestine are reduced; the passage of chyme is slowed-constipation may occur, spasm may be relieved.  However,  peristalsis is only incompletely suppressed, because it is primarily regulated by local reflexes in the enteric plexus, and other neurotransmitters (5-HT,  enkephalin, etc.,) are involved. Enhanced motility due to injected cholinergic drugs is more completely antagonised than that due to vagal stimulation, because intramural neurons which are activated by vagus utilize a number of noncholinergic transmitters as well. Reference: Essentials of Medical Pharmacology Eighth Edition KD  TRIPATHI  page no 125,126

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