Which of the following is not a clinical sign of atropine intoxication?
High-Yield Explanation
Atropine is an anticholinergic drug. It will decrease GI motility.
PHARMACOLOGICAL ACTIONS of Atropine:
Atropine blocks all subtypes of muscarinic receptors.
Tone and amplitude of contractions of stomach and intestine are reduced; the passage of chyme is slowed-constipation may occur, spasm may be relieved. However, peristalsis is only incompletely suppressed, because it is primarily regulated by local reflexes in the enteric plexus, and other neurotransmitters (5-HT, enkephalin, etc.,) are involved.
Enhanced motility due to injected cholinergic drugs is more completely antagonised than that due to vagal stimulation, because intramural neurons which are activated by vagus utilize a number of noncholinergic transmitters as well.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 125,126