Drug of choice for typhoid fever:

Ans: a (Ciprofloxacin) Ref: Harrison, 16th ed,p. 900Ciprofloxacin is the drug of choice for enteric fever, dose is 500 mg PO b.i.d for 10 days.The Table gives below is from Harrison. 17th edition.Antibiotic therapy for enteric fever in adultsIndicationAgentDosage (Route)Duration, DaysEmpirical Treatment Ceftriaxone1-2 g/d (IV)7-14 Azithromycin1 g/d (PO)5Fully Susceptible Ciprofloxacin (first line)500 mg bid (PO) or 400 mg q12h (IV)5-7 Amoxicillin (second line)1 g tid (PO) or 2 g q6h (IV)14 Chloramphenicol25 mg/kg tid (PO or IV)14-21 Trimethoprim-160/ 800 mg bid (PO)14 sulfamethoxazole Multidrug--Resistant Ciprofloxacin500 mg bid (PO) or 400 mg q12h (IV)5-7 CeftriaxoneAzithromycin2-3 g/d (IV)1 g/d (poy7-145Nalidixic Acid-Resistant Ceftriaxone1-2 g/d (IV)7-14 Azithromycin1 g/d (PO)5 High-dose ciprofloxacin750 mg bid (PO) or 400 mg q8h (IV)10-14