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Pharmacology General 97588d92

Mannitol decreases the intraocular pressure by ?

A
Withdrawing water from vitreous
B
Increasing uveoscleral outflow
C
Increasing aqueous through trabecular meshwork
D
Inhibiting the enzyme carbonic anhydrase in the ciliary body
High-Yield Explanation
Ans. is 'a' i.e., Withdrawing water from vitreous By osmotic action mannitol encourages movement of water from aqueous humour --> decrease. Mannitol is used in angle closure (narrow angle, acute congestive) glaucoma. Treatment of acute congestive glaucoma o Definitive therapy is surgery (laser iridotomy) Drugs are used to decrease the i.o.t. during an acute attack. o Approch is : Sta i.v. mannitol or i.v. acetazolamide When i.o.t. stas falling, sta topical pilocarpine or b -blocker (timolol). Apraclonidine/latanoprost may be added. Once i.o.t. is reduced, surgery is done.

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