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Pharmacology General 97149cab

All of the following diuretics inhibit Na+.K+.2Cl- symporter, EXCEPT:

A
Thiazide
B
Furosemide
C
Ethacrynic acid
D
Mersalyl
High-Yield Explanation
1. High efficacy diuretics (Inhibitors of Na-K-2Cl cotransport) Sulphamoyl derivatives - Furosemide, Bumetanide, Torsemide. 2.Medium efficacy diuretics (Inhibitors of Na-Cl symport) (a) Benzothiadiazines (thiazides)- Hydrochlorothiazide, Benzthiazide, Hydroflumethiazide, Clopamide. (b) Thiazide-like (related heterocyclics) - Chlorthalidone, Metolazone, Xipamide, Indapamide. 3. Weak or adjunctive diuretics (a) Carbonic anhydrase inhibitors - Acetazolamide. (b) Potassium-sparing diuretics. (i) Aldosterone antagonist: Spironolactone  (ii) Inhibitors of the renal epithelial Na+ channel: Triamterene, Amiloride. (c) Osmotic diuretics - Mannitol, Isosorbide, Glycerol.

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