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Biochemistry Enzymes 9698f339

The active site of an enzyme will bind to which of the following set of molecules indicated?

A
Substrate of the Reaction - Yes; Allosteric Inhibitors - Yes; Competitive Inhibitors - Yes; Non-competitive Inhibitors - Yes
B
Substrate of the Reaction - Yes; Allosteric Inhibitors - No; Competitive Inhibitors - Yes; Non-competitive Inhibitors - Yes
C
Substrate of the Reaction - No; Allosteric Inhibitors - No; Competitive Inhibitors - Yes; Non-competitive Inhibitors - No
D
Substrate of the Reaction - No; Allosteric Inhibitors - No; Competitive Inhibitors - No; Non-competitive Inhibitors - No
High-Yield Explanation
The active site is formed when the enzyme folds into its three-dimensional configuration and may involve amino acid residues that are far apart in the primary sequence. Substrate molecules bind at the active site, as will competitive inhibitors (because the inhibitor reduces enzyme activity by competing with substrate for binding at the active site). Allosteric inhibitors bind at a site other than the active site, as do noncompetitive inhibitors (which reduce the Vmax without affecting the Km ).

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