Pathology General 969442e8

The pathogenesis hypochromic anemia in lead poisoning is due to -

Inhibition of enzymes involved in heme biosynthesis

Binding of lead to transferrin, inhibiting the transpo of iron

Binding of lead to cell membrane of erythroid precursors

Binding of lead to ferritin inhibiting their breakdown into hemosiderin

High-Yield Explanation

Ans. is 'a' i.e., Inhibiton of enzymes involved in Heme biosynthesis o Lead interferes with the syntheiss of Heme by inhibiting the enzymes d Aminolevulinic acid dehydrase and Ferrochelatase. These two enzymes are involved in the synthesis of Heme.

The pathogenesis hypochromic anemia in lead poisoning is due to -

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