Intense depression & misery without any cause is?

Melancholic depression - A. Prominent biological symptom 1. Early morning awakening (waking up at least 2 hours before usual time) 2.Significant anorexia and weight loss. B. Significant psychomotor agitation or retardation. C. Anhedonia and lack of mood reactivity.(the patients mood doesn't improve even if some positive event occurs ) D. A distinct quality of intensely depressed mood, often referred to as a state of despondency or despair,also called empty mood.the patients feels miserable. E. Depression is worse in morning. F. Excessive guilt.