DIC may be caused by: September 2007

Ans. C: Amniotic fluid embolismDisseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving the generation of intravascular fibrin and the consumption of procoagulants and platelets. The resultant clinical condition is characterized by intravascular coagulation and hemorrhage. Conditions associated with disseminated intravascular coagulationSepsis/severe infectionTrauma (neurotrauma)Organ destructionMalignancy (solid and mveloproliferative malignancies)Severe transfusion reactionsRheumatologic illness-Adult Stills disease, LupusObstetric complications- Amniotic fluid embolism, abruption placentae, hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome/ eclampsia, Retained dead fetus syndromeVascular abnormalities-Large vascular aneurysmsSevere hepatic failureSevere toxic reactions-Envenomation, Transplant rejection, transfusion reactions