Pharmacology Anesthesia 95807a18

All of the following statements about lignocaine are true except

It blocks active sodium channels with more affinity than resulting sodium channels

It can cause cardiotoxicity

It is given orally for treatment of cardiac arhymias

Adrenaline increases the duration of action of lignocaine when used for infiltration anesthesia

High-Yield Explanation

All local anesthetics are weak bases.These drugs act by penetrating the axonal membrane and blocking the voltage gated sodium channels within Vasoconstrictors like adrenaline can prolong the duration of action. All LA can cause cardiotoxicity and neurotoxicity

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