Pathology General 956839ed TSC1 gene plays a vital role in pathogenesis of a neurocutaneous syndrome called Tuberous sclerosis. It is located on which chromosome? A Chromosome 16 B Chromosome 9 C Chromosome 4 D Chromosome 3 High-Yield Explanation TSC1 gene is located on Chromosome 9. TSC2 gene is located on Chromosome 16.