Full 2L QBank
Biochemistry Glycogen 95220c32

In glycogen metabolism, a metabolically active impoant enzyme found in liver is conveed from it's inactive dephosphorylated state to it's active phosphorylated state. Which of the following is true about this enzyme:

A
Phosphorylation sometimes activates the enzyme
B
Catecholamines directly stimulate it
C
More commonly seen in fasting state than in fed state
D
Always activated by cAMP dependent protein kinase
High-Yield Explanation
The enzyme in concern in this question is Glycogen Phosphorylase: Glycogen Phosphorylase RLE of glycogenolysis Active in phosphorylated state. Phosphorylation always activates this enzyme. (option A is wrong) Catecholamines stimulate this enzyme through cAMP, not directly. (option B is wrong) Glycogenolysis is occurring in fasting state, not in fed state. CAMP activates this enzyme but Calcium & calmodulin directly activates this enzyme without phosphorylation and without cAMP. (option D is wrong as this enzyme is not always activated by cAMP).

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