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Social & Preventive Medicine General 94b4198a

False statement regarding japanese encephalitis is: March 2010

A
It is caused by flavivirus
B
Transmitted by aedes mosquito
C
Not endemic in India
D
Man is dead-end host
High-Yield Explanation
Ans. B: Transmitted by aedes mosquito The Japanese encephalitis virus is a virus from the family Flaviviridae. Domestic pigs and wild birds are reservoirs of the virus; transmission to humans may cause severe symptoms. Man is an incidental dead-end host. One of the most impoant vectors of this disease is the mosquito Culex tritaeniorhynchus. This disease is most prevalent in Southeast Asia, especially in Japan, china, and Korea. The causative agent Japanese encephalitis virus is an enveloped virus of the genus flavivirus; it is closely related to the West Nile virus and St. Louis encephalitis virus. Positive sense single stranded RNA genome is packaged in the capsid, formed by the capsid protein. It has been noted that the Japanese encephalitis virus (JEV) infects the lumen of the endoplasmic reticulum (ER) and rapidly accumulates substantial amounts of viral proteins for the JEV. Japanese Encephalitis is diagnosed by detection of antibodies in serum and CSF (cerebrospinal fluid) by IgM capture ELISA

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