In Bater syndrome the defect lies in?
High-Yield Explanation
Bater Syndrome- defect in thick ascending limb of loop of Henle *Loss of function of (Na+ Cl- K+ co transpoer) *Damage to ROMK & Cl- channel C/F: 1. Hypokalemia, salt wasting 2. Normal BP 3.Met. Alkalosis Dx: 24 hr. urine chloride : elevated *24 hr. urine Ca2+ : elevated DOC: indomethacin