Which of the following do not crosses the blood brain barrier

(Pralidoxime) (92, 83-KDT) (105-KDT 6th)Lipid soluble agents (physostigmine and organophosphates) have more marked muscarinic and CNS effects; stimulates ganglia but action on skeletal muscle is less prominentLipid insoluble agents (neostigmine and other quaternary ammonium compounds) produces more marked effect on the skeletal muscles (direct action on muscle end-plate cholinoceptors as well), stimulate ganglia, but muscarinic effects are less prominent. They do not penetrate CNS and have no central effects.Pralidoxime (quartenary nitrogen) it causes more marked reactivation of skeletal muscle. ChE than at autonomic sites and not at all in the CNS (does not penetrate)* Other oximes are obidoxime (more potent than pralidoxime) and diacetyl-monoxime (DAM). DAM lacks quaternary nitrogen and is lipophilic.