Full 2L QBank
General Medicine General 94800310

Which of the following is the primary defect which leads to sickle cell anemia?

A
A nonsense mutation in the b-chain of HbA
B
An abnormality in porphyrin pa of hemoglobin
C
Replacement of glutamate by valine in b-chain of HbA
D
Substitution of valine by glutamate in the a-chain of HbA

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