Pediatrics Congenital CNS malformations 945851cf Most specific congenital abnormality in a baby born to a diabetic woman is? A Ventricular Septal defect B Sacral agenesis C Meningomyelocele D Transposition of great aeries High-Yield Explanation -Sacral agenesis or Caudal regression syndrome is the most specific congenital abnormality in a baby born to a diabetic woman.