A major causal factor in some cases of hypogonadism is:

Ans. A. Reduced secretion of gonadotropin-releasing hormone (GnRH)Reduced secretion of GnRH will result in extremely low levels of circulating LH and FSH, causing testicular atrophy, as in Kallmann's syndrome. Hypersecretion of LH and FSH, increased activin, and an increased number of FSH receptors all lead to hyperfunction of the testis, not hypofunction. A failure of the hypothalamus to respond to testosterone increases LH, leading to increased Leydig cell androgens and testicular hypertrophy