Absence of Corpus callosum leads to

Agenesis of corpus callosum is a rare bih defect (congenital disorder) in which there is complete or paial absence of corpus callosum. Corpus callosum is a band of tissue connecting the two hemispheres of the brain. Fibres of corpus callosum arise from the superficial layers of the cerebral coex and they project to the homotypic regions of the contralateral coex by passing through the corpus collosum while crossing the midline. Signs and symptoms of agenesis of corpus callosum vary greatly among individuals. Patients usually do not have any neurological manifestations. However, some features common in agenesis of corpus callosum are:- Vision impairment * Low muscle tone (hypotonia) Poor motor coordination * Delay in motor milestones such as sitting and walking. Low perception of pain * Delayed toilet training * Chewing and swallowing difficulties * Early speech and language delays REF: Ganong 22ed chapter 37, HARRISON 21ST EDITION)