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Physiology General 935dfd00

Which of the following directly inhibits insulin secretion?

A
Alpha2-adrenergic agonist
B
Beta2-adrenergic agonist
C
Cholecystokinin
D
Glucagon
High-Yield Explanation
Alpha 2-receptor agonists directly inhibit pancreatic insulin secretion. Beta2-adrenergic agonists stimulate insulin secretion. Cholecystokinin is a hormone that not only causes gallbladder contraction, but also causes insulin secretion from the pancreas. Pancreatic glucagon release acts as a paracrine stimulus for insulin secretion. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 25. Overview of Gastrointestinal Function & Regulation. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.

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