Alzeihmer's disease is associated with

Patients with trisomy 21 have 3 copies of the gene for amyloid precursor protein and develop neurological characteristics of Alzheimer's disease by midlife. Alzheimer's Disease in People with Down Syndrome. Many, but not all, people with Down syndrome develop Alzheimer's disease when they get older. People with Down syndrome are born with an extra copy of chromosome 21, which carries the APP gene. This gene produces a specific protein called amyloid precursor protein (APP) .which leads to development of Alzheimer's Ref Harrison20th edition pg 2756