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Pharmacology C.N.S 92a00913

Which of the following is not a MAO-B inhibitor?

A
Safinamide
B
Selegiline
C
Rasagiline
D
Cariprazine
High-Yield Explanation
Ans. D. Cariprazinea. Safinamide is the latest MAO-B inhibitor for Parkinson's disease. Unlike the previous two, it is a reversible MAO- B inhibitor. Safinamide also has other actions including inhibition of glutamate release and dopamine and serotonin reuptake. It is used as an add-on drug to Levodopa therapy for reducing "off" episodesb. Cariprazine a partial D3 agonist used as anti-psychotic

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