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Medicine General 923a44c4

Pulmonary fibrosis is associated with the use of which of the following drugs?

A
Bleomycin
B
Cisplatin
C
Methotrexate
D
Actinomycin D
High-Yield Explanation
Out of all the options given bleomycin and methotrexate can cause pulmonary toxicity. But pulmonary fibrosis is the most feared complication of Bleomycin. Ref: Harrison's 16th Edition, Page 471 (table 70-2); Drug-Induced Diseases: Prevention, Detection, and Management, By James E. Tisdale, Douglas A. Miller, Page 360, table 21-1 (ASHP, 23-Jan-2010)

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