Regarding prion protein which of the following statment is true:

Prions propagate by transmitting a misfolded protein state Alteration in the conformation of the protein Normal a-helix structure is conveed to b-sheet structure. Acts as a template to guide the misfolding of more protein into prion form. Aggregations of these abnormal isoforms form highly structured amyloid fibers, This altered structure is extremely stable, insoluble and accumulates in infected tissue Causing tissue damage and cell death