Cytokines are secreted in sepsis and Systemic Inflammatory Response syndrome (SIRS) by -

Cytokine release in Sepsis The mechanism by which endotoxin causes activation of inflammatory cells and release of cytokines has already been explained earlier. It is by TL -4 and CD-14 mediated. Signals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators. The major cells that secrete cytokines in sepsis area Monocyte/Macrophages       Neutrophils                     Endothelial cells Cytokine mediators involved are:- TNF - (The most important cytokine in sepsis)               IL-1                    IL-6       IL-8               NO.