Which of the following vascular lesions has the LEAST clinical significant

Monckeberg&;s medial calcification has the least clinical significance. It represents dystrophic calcification (often visible on x-ray) in the media of muscular aeries. Luminal occlusion does not occur.Aeriolosclerosis is a subclass of aeriosclerosis that primarily involves the aerioles. Hyperplastic aeriolosclerosis involves smooth muscle hyperplasia in the muscle wall with an "onion skin" appearance; This change is paicularly prominent in the kidneys of patients with malignant hypeension or progressive systemic sclerosis. Hyaline aeriolosclerosis is a small vessel disease associated with diabetes mellitus and essential hypeension.A po wine nevus flammeus in the trigeminal distribution is often associated with Sturge-Weber syndrome. Glomus tumors (glomangiomas) are painful, benign tumors of modified smooth muscle that are usually located directly beneath the nail bed.