Basophilic stippling is seen with

i.e. (Thalassaemia) : (292-Harsh mohan 6th) (658-H17th/6th)Punctate basophilia or basophilic stippling is diffuse and uniform basophilic granularity in the cell which does not stain positively with Perl's reaction (in contrast to pappenhamer bodies which stain positively)Examples -* Aplastic anaemia* Thalassaemia* Myelodysplasia* Infections* Lead poisoning* Howell -Jolly bodies - present in Megaloblastic anemia and after splenectomy* Basophilic leucocytosis indicative of CML**PYRIMIDINE 5' - NUCLEOTIDASE (PSN) DEFICIENCY - Highly distinctive feature of this condition is a morphological abnormality of the red cells known as basophilic stippling. This condition is rare but it probably ranks third in frequency among red cell enzyme defects (after G6PD deficiency and pyruvate Kinase deficiency) (658-H17th)