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Biochemistry vitamins 9168d095

Which of the followingg is true about Vitamin K:

A
Vitamin K is needed for action of clotting factor VIII
B
Vitamin K is required for bone health
C
Vitamin K deficiency leads to DVT
D
Vitamin K is a water soluble Vitamin
High-Yield Explanation
Vitamin K is required for bone health. Vitamin K is involved in post translational modification of calcium binding proteins and several vitamin K-dependent proteins play an impoant role in maintaining bone and cailage health. Three most widely studies vitamin K-dependent proteins implicated in bone health are osteocalcin (Bone Gla protein), Matrix Gla protein (MGP) and Protein S, all of these proteins undergo post-translational carboxylation of glutamic acid (Gla proteins) for which vitamin K is a cofactor. Vitamin K is a fat soluble Vitamin (Not water soluble). Vitamin K is required in the hepatic synthesis of prothrombin an blood clotting factors II, VII, IX and X (Not for clotting factor VIII). Deficiency of Vitamin K leads to delay in coagulation and bleeding disorders (Not DVT) Ref: Harper

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