Clearance-

Ans. is 'd' i.e., All of the above o Clearance of a drug is the theoretical volume of plasma from which the drug is completely removed in unit time,o It refers to efficacy of elimination of a drug:Clearance =Rate of eliminationPlasma concentrationo As drug is to be removed from plasma in unit time, clearance can not be greater than blood flow to an organ.o Steady state plasma concentration is determined by t 1/2 . t 1/2 is dependent on clearance :154=0-693 xVCLSo, clearance determines the steady state plasma concentration.