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Pharmacology Anti Adrenergic System 910111e8

Wrong about prazosin is :

A
a2 presynaptic blocker
B
Orally effective
C
Metabolised in liver
D
First dose effect may occur
High-Yield Explanation
Ans. is 'a' a2 presynaptic blocker Reference KDT 5th p. 121 (4th/e page 135)Prazosin is a highly selective a1 blaker*It producers first dose effect* (Postural hypotension in the beginning)*It is highly bound to proteins, metabolized in liver* and primarily excreted in bile.It dilates arterioles more than veins.

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