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General Medicine General 90e53066

Despite their sho half-lives (2 hours), Proton pump Inhibitors (PPIs) cause a prolonged suppression of acid secretion (up to 48 hours) because:

A
They are prodrugs and undergo activation gradually
B
They exit from the plasma and enter acid secretory canaliculi and stay there, blocking the secretion of acid for a long time
C
They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps
D
They are available as enteric coated capsules, from which drug is gradually released
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