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Medicine General 90cc01e6

A hypeensive diabetic is having proteinuria, antihypeensive of choice is:

A
Propanolol
B
Clonidine
C
Enalaprilat
D
Alpha methyldopa
High-Yield Explanation
Answer is C (Enalaprilat) The presence of proteinuria in this diabetic patient suggest a diagnosis of diabetic nephropathv. The drugs of choice for management of hypeension in patients with diabetes are ACE inhibitors Enalapril is an ACE inhibitor and the drug of choice for management of hypeension in patients with diabetic nephropathv. ACE inhibitors or Angiotensin blockers should be the first line therapy in hypeensive individuals with type 2 Diabetes. They have no known adverse effect on glucose or lipid metabolism and minimize the development of diabetic nephropathy by reducing renal vascular resistance and renal perfusion pressure- Harrison Indication - Treatment of choice Hypeensive patient with protenuriae - ACE inhibitors or Angiolensin Blocker Hypeensive patient with Diabetese - ACE inhibitors or Angiotensin Blocker Hypeensive patient with diabetic Nephropathye - ACE inhibitor or Angiotensin Blocker ACE inhibitors have become the drug of choice for chronic renal disease whether diabetic or non diabetic in origin.

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