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Medicine General 908c0b0d

True regarding Felty's syndrome are all except:

A
Splenomegaly
B
Neutrophilia
C
Female preponderance
D
Associated with rheumatoid ahritis
High-Yield Explanation
Ans. B: Neutrophilia Felty syndrome is a potentially serious condition that is associated with rheumatoid ahritis. Felty syndrome affects 1-3% of all individuals with rheumatoid ahritis, and rheumatoid ahritis occurs in about 1% of the general population. In those diagnosed with the disorder, women outnumber men 3 to 1. Felty syndrome is most likely an autoimmune disorder. In Felty's syndrome triad of rheumatoid ahritis, splenomegaly and neutropenia is seen. Spleen produced antibodies reduces the neutrophil life span and hence splenectomy may increase the neutrophil count in Felty's syndrome. Risk factors for Felty syndrome include long-standing rheumatoid ahritis that is severe and high positive titer for rheumatoid factor.

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