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Pharmacology Anti-Neoplastic Agents 903f0088

True about Azathioprine is?

A
It has more anti tumor effect than immunosuppressant effect
B
It is not a prodrug
C
It selectively affects differentiation of T cells
D
It is a pyramidine antimetabolite
High-Yield Explanation
ANSWER: (C) It selectively affects differentiation of T cellsREF: KDT 6th ed p. 840AZATHIOPRINEPurine antimetaboliteMore marked immunosuppressant effect than antitumour effectIt's a prodrug and converted to more active 6-mercaptopurineSelectively inhibits T cell differentiation and function of T cellsMost important application - graft rejections/e - bone marrow suppression

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