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Pharmacology General 90302dc1

Nitrates decrease myocardial oxygen consumption by all of the following mechanisms except -

A
By increasing the left ventricular end diastolic pressure
B
By direct reduction of oxygen consumption of the myocardial cell
C
By dilation of the capacitance vessels
D
By decreasing the size of hea
High-Yield Explanation
Ans. is 'a' i.e., By increasing the left ventricular end diastolic pressure o Nitratets dilate veins (capacitance) vessels and decrease venous return (preload)o This results in decreased end diastolic pressure and left ventricular size (not increased), which ultimately leads to decreased oxygen consumption.

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