In a controlled trail to compare two treatments. the main purpose of randomization is to ensure that ?

Ans. is 'a' i.e., The two groups will be similar in prognostic factors o "Randomization is a statistical procedure by which the paicipatnts are allocated into groups usually called `study' and 'control' groups, to receive or not to receive an experimental , preventive or therapeutic procedure, manoeuvre or intervention. o Randomization is an attempt to eliminate 'bias' and allow for comparability. Theoretically it is possible to assure comparablity by matching . But when one matches, one can only match, those factors which are known to be impoant. There may be other factors which are impoant but whoese effect is not recognized or cannot be determined. By a process of randomization, hopefully these factors will be distributed equally between the two groups. o Randomization will give the greatest confidence that the groups are comparable." o About other options Options (b) and (d) o The clinician knowing or not knowing about the treatment the subjects will receive, is pa of Blinding and not randomization. Option (c) o Both the 'study' and 'control' samples are derived from the reference population. This is a step taken prior to randomization. o First an experimental or study population is selected from a known population (the target or reference population). Later this study population in divided into study and control groups by Randomization.