The least extrapyramidal side effects are seen with the following phenothiazine
High-Yield Explanation
Side effects of impoant CNS drugs Midazolam Ataxia , Blackouts in elderlyTolcapone Hepatotoxic Phenytoin Hirsuitism , Gingival hyperplasia , Osteomalacia , Teratogen , Megaloblastic anemia , Ataxia , Lymphadenopathy , Hyperglycemia , Arrhythmias , Vitamin K deficiency Valproate Irreversible hepatic necrosis in older children , Acute pancreatitis Zonisamide , Topiramate Renal stones VigabatrineIrreversible visual field defectsFelbamate Aplastic anemia Thioridazine Male sexual dysfunction , Retinal damage , Least extra pyramidal symptomsClozapine Agranulocytosis , Myocarditis Risperidone Extra pyramidal symptoms HaloperidolExtra pyramidal symptoms , Akathisia Olanzapine Risk of stroke and death Ziprasidone , Pimozide QT prolongation Quetiapine Cataract Iloperidone Ohostatic hypotension Lithium in expectant mothers Ebstein's anomalyFormic acid Retinal damage Opioids Tolerance & addiction