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Pharmacology C.V.S 8ebea96e

A patient of prinzmetal's angina is started on isosorbide mononitrate. What is the mechanism of action of nitrates in this condition?

A

Reduced cardiac contractility

B

Increased left ventricular end diastolic volume

C

Decreased diastolic perfusion pressure

D

Endothelium independent coronary vasodilation

High-Yield Explanation

Ans. (D) Endothelium independent coronary vasodilation(Ref: KDT 7th/e p541)Predominant mechanism of action of nitrates in angina:*In Classical angina: Decrease in preload*In Variant angina: Coronary vasodilation

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