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Psychiatry General 8e77ac52

Mechanism of action of duloxetine is ?

A
Selective Inhibition of serotonin reuptake
B
Selective inhibition of nor-epinephrine reuptake
C
Selective inhibition of both serotonin and nor-epinephrine reuptake
D
None of the above
High-Yield Explanation
Ans. C. Selective inhibition of both serotonin and nor-epinephrine reuptakeDuloxetine, is a drug classified under serotonin-norepinephrine reuptake inhibitors (sNRJs).At lower doses it is more prominent serotonin reuptake inhibitor.Whereas at higher doses it is more prominent inhibitor of nor-epinephrine reuptake.It has minimal dopamine agonist action.

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